Whether you spend your time tooling around in-town or are venturing out on the open road, if you value paying as little as possible for each mile driven, then the Toyota Prius should be on your shopping list. Not many cars get the outstanding fuel economy of the Prius family.
Yes, you will pay a bit more for a hybrid versus a gasoline-powered car. But, if you are putting a lot of miles on your car or like the ability to cruise around town in pure electric mode like the plug-in version offers, then the additional initial expense will be worth it to you. The reliability of the Prius and being the market-leading hybrid should give you confidence that this car will be in your garage for many, many years.